Mechanisms of Neuromodulation as Dissected Using Sr2+ at Motor Nerve Endings

Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings.

The use of binomial analysis as a tool for determining the sites of action of neuromodulators may be complicated by the nonuniformity of release probability. One of the potential sources for nonuniformity of release probability is the presence of multiple forms of synaptotagmins, the Ca2+ sensors responsible for triggering vesicular exocytosis. In this study we have used Sr2+, an ion whose acti...

Mechanisms of Neuromodulation as Dissected Using Sr at Motor Nerve Endings

Searl TJ, Silinsky EM. Mechanisms of neuromodulation as dissected using Sr at motor nerve endings. J Neurophysiol 99: 2779–2788, 2008. First published April 2, 2008; doi:10.1152/jn.90258.2008. The use of binomial analysis as a tool for determining the sites of action of neuromodulators may be complicated by the nonuniformity of release probability. One of the potential sources for nonuniformity...

Spontaneous subthreshold activity at motor nerve endings.

Motor Nerve Endings of Twitch Muscle Fibers in Hippocampus Hudsonius

Two protein trafficking processes at motor nerve endings unveiled by botulinum neurotoxin E.

The unique ability of a family of botulinum neurotoxins to block neuroexocytosis specifically-by selective interaction with peripheral cholinergic nerve endings, endocytotic uptake, translocation to the cytosol, and enzymic cleavage of essential proteins-underlies their increasing therapeutic applications. Although clinical use of type A is most widespread due to its prolonged inactivation of t...